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Acute tumour lysis syndrome in a dog with B‐Cell multicentric lymphoma
Author(s) -
Mylonakis ME,
Koutinas AF,
Papaioannou N,
Lekkas S
Publication year - 2007
Publication title -
australian veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 59
eISSN - 1751-0813
pISSN - 0005-0423
DOI - 10.1111/j.1751-0813.2007.00127.x
Subject(s) - medicine , vincristine , cyclophosphamide , prednisolone , lymphoma , lymph node , pathology , jaundice , chemotherapy , canine lymphoma , gastroenterology
A 5‐year‐old, spayed female German Shepherd dog was admitted to hospital with marked generalised lymphadenomegaly and splenomegaly. A stage Va B‐cell multicentric lymphoma was diagnosed on clinical, cytological (lymph node, bone marrow), histological‐immunohistochemical (lymph node excision) and imaging grounds. Since no satisfactory remission was achieved using a multi‐drug chemotherapy protocol that included cyclophosphamide, vincristine, cytosine arabinoside, prednisolone, and subsequently supplemented by L‐asparaginase, it was replaced by another protocol combining vincristine, L‐asparaginase, prednisolone, cyclophosphamide and doxorubicin. Soon after the third weekly session of the second protocol, the clinical status of the animal deteriorated suddenly and severely, with a bleeding tendency, jaundice, hyperuricaemia, hyperphosphataemia, azotaemia, hyperbilirubinaemia and, presumptive disseminated intravascular coagulation. There was also complete regression of lymphadenomegaly. This report emphasises the clinicopathological features and the diagnostic peculiarities of the acute tumour lysis syndrome, which occurs uncommonly in dogs.