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Successful management of histiocytic ulcerative colitis with enrofloxacin in two Boxer dogs
Author(s) -
DAVIES DR,
O'HARA AJ,
IRWIN PJ,
GUILFORD WG
Publication year - 2004
Publication title -
australian veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 59
eISSN - 1751-0813
pISSN - 0005-0423
DOI - 10.1111/j.1751-0813.2004.tb14643.x
Subject(s) - enrofloxacin , histiocyte , ulcerative colitis , medicine , colonoscopy , prednisolone , colitis , gastroenterology , infiltration (hvac) , pathology , antibiotics , colorectal cancer , disease , biology , physics , thermodynamics , cancer , microbiology and biotechnology , ciprofloxacin
Two Boxer dogs with histologically confirmed histiocytic ulcera‐tive colitis were treated with enrofloxacin, one as sole therapy and one in conjunction with prednisolone, after failure of standard therapy. Clinical remission occurred rapidly in both dogs after commencement of enrofloxacin and in one case where repeat colonoscopy was performed the endoscopic appearance of the mucosa was normal within 2 weeks. Histological examination of the colonic mucosa in this dog after 7 months showed resolution of the cellular infiltration characteristic of histiocytic ulcerative colitis. Histological improvement following therapy in Boxer dogs with histiocytic ulcerative colitis has not been reported previously.