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Squamous cell carcinoma with sarcomatous stroma in the nasal cavity of a dog
Author(s) -
BOSWARD KL,
KESSELL AE,
LUCY RJ
Publication year - 2004
Publication title -
australian veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 59
eISSN - 1751-0813
pISSN - 0005-0423
DOI - 10.1111/j.1751-0813.2004.tb11200.x
Subject(s) - cytokeratin , pathology , desmin , nasal cavity , vimentin , stroma , keratin , immunohistochemistry , medicine , carcinoma , anatomy
This is a report of an unusual squamous cell carcinoma in the nasal cavity of a dog. A 13‐year‐old Golden Retriever was presented with a unilateral nasal and ocular discharge. Although a nasal tumour was suspected, initial diagnostic investigations were unrewarding, and, with worsening clinical signs, the dog was euthanased. Necropsy examination confirmed the presence of a nasal tumour that was composed histologically of both a well‐differentiated squamous cell carcinoma component blending with a predominant spindle cell component. Immunohistochemical staining with anti‐human keratin/cytokeratin (AE1/AE3, CAM 5.2 and broad spectrum cytokeratin), Vimentin, Desmin, smooth muscle actin and S‐100 protein supported a diagnosis of a squamous cell carcinoma with (pseudo) sarcomatous stroma.