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Effect of solute lipophilicity on penetration through canine skin
Author(s) -
MILLS PC,
MAGNUSSON BM,
CROSS SE
Publication year - 2003
Publication title -
australian veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 59
eISSN - 1751-0813
pISSN - 0005-0423
DOI - 10.1111/j.1751-0813.2003.tb14608.x
Subject(s) - lipophilicity , penetration (warfare) , chemistry , mathematics , stereochemistry , operations research
Objective To investigate the effect of lipophilicity on the percutaneous penetration of a homologous series of alcohols through canine skin Design Skin harvested from Greyhound thorax was placed in Franz‐type diffusion cells and the in vitro passage of radio‐labelled ( 14 C) alcohols (ethanol, butanol, hexanol and octanol (Log P 0.19 ‐ 3.0)) through separate skin sections was measured in replicates of five. Permeability coefficient (k P , cm/h), maximum flux ( J max , mol/cm 2 /h) and residue remaining within the skin were determined. Results The k P increased with increasing lipophilicity (6.2 times 10 ‐4 ± 1.6 times 10 ‐4 cm/h for ethanol to 1.8 times 10 ‐2 ± 3.6 times 10 ‐3 cm/h for octanol). Alcohol residues remaining within each skin sample followed a similar pattern. An exponential decrease in J max with increasing lipophilicity was observed. Conclusion Changes in canine skin permeability occur with increasing alcohol lipophilicity. This finding has practical consequences for the design of topical formulations and optimisation of drug delivery through animal skin.