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The efficacy of formulations of triclabendazole and ivermectin in combination against liver fluke ( Fasciola hepatica ) and gastro‐intestinal nematodes in cattle and sheep and sucking lice species in cattle
Author(s) -
STEVENSON CR,
MAHONEY RH,
FISARA P,
STREHLAU G,
REICHEL MP
Publication year - 2002
Publication title -
australian veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 59
eISSN - 1751-0813
pISSN - 0005-0423
DOI - 10.1111/j.1751-0813.2002.tb11303.x
Subject(s) - triclabendazole , fasciola hepatica , ivermectin , biology , veterinary medicine , liver fluke , fasciola , hepatica , fasciolosis , infestation , zoology , helminths , medicine , agronomy , immunology
Objective To assess the efficacy of two formulations of triclabendazole and ivermectin in combination against liver fluke ( Fasciola hepatica ), gastro‐intestinal nematodes and sucking louse species in cattle and sheep. Procedure A study of 540 cattle and 428 sheep at 18 sites throughout Victoria and New South Wales was undertaken. At each site, one group of cattle or sheep was treated with a combined formulation (Fasimec® Cattle or Fasimec® Sheep), another received ivermectin and triclabendazole separately. In trials on lice infestation, an additional group remained untreated. Samples for faecal egg counts were collected on days ‐7, 0 (treatment day), +7, +14 and +21 after treatment. Lice assessments were carried out on days −7, 0, +7, +14, +28, +42 and +56. Results Both treatments were highly efficacious (> 98% efficacy) against liver fluke in cattle and sheep, against three sucking lice species of cattle and against gastro‐intestinal nematodes in sheep. There was also no significant difference between treatments in efficacy. Against gastro‐intestinal nematodes, Fasimec® Cattle was significantly (P<0.01) more effective than the separately applied ivermectin and triclabendazole treatment. Mean efficacy for the Fasimec Cattle and Ivomec/Fasinex 120 groups respectively, was 97.6% and 94.2% on Day +7, 98.9% and 91% on Day +14 and 98.5% and 92.6% on Day +21. Conclusion The efficacy of Fasimec ® Cattle and Fasimec ® Sheep was at least equal to that of currently registered products (with the same active ingredients) used to control these parasites.