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Hypercalcaemia associated with chronic lymphocytic leukaemia in a Giant Schnauzer
Author(s) -
KLEITER M,
HIRT R,
KIRTZ G,
DAY MJ
Publication year - 2001
Publication title -
australian veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 59
eISSN - 1751-0813
pISSN - 0005-0423
DOI - 10.1111/j.1751-0813.2001.tb12007.x
Subject(s) - polydipsia , lethargy , lymphocytosis , polyuria , medicine , hypercalcaemia , chlorambucil , bone marrow , pathology , prednisolone , population , vomiting , gastroenterology , endocrinology , chemotherapy , cyclophosphamide , environmental health , calcium , diabetes mellitus
A 7‐year‐old male Giant Schnauzer was referred with a history of severe vomiting, lethargy, weight loss, polydipsia and polyuria. Detailed investigations revealed leucocytosis with a marked lymphocytosis, mild non‐regenerative anaemia, thrombocytopenia, hypercalcaemia and azotaemia. Circulating lymphocytes were small and well‐differentiated, and the same lymphoid population was present in bone marrow. Chronic lymphocyctic leukaemia with associated paraneoplastic hypercalcaemia was diagnosed. Immunohistochemical staining of a bone marrow biopsy revealed a neoplastic B‐cell line expressing CD79. The dog responded to therapy with prednisolone and chlorambucil for a period of 8 months.