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Principles for the use of macrocyclic lactones to minimise selection for resistance
Author(s) -
DOBSON RJ,
BESIER RB,
BARNES EH,
LOVE SCJ,
VIZARD A,
BELL K,
JAMBRE LF
Publication year - 2001
Publication title -
australian veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 59
eISSN - 1751-0813
pISSN - 0005-0423
DOI - 10.1111/j.1751-0813.2001.tb10892.x
Subject(s) - moxidectin , avermectin , pasture , ivermectin , abamectin , resistance (ecology) , selection (genetic algorithm) , toxicology , microbiology and biotechnology , veterinary medicine , biology , medicine , pesticide , agronomy , computer science , anatomy , artificial intelligence
Objective To provide principles for the appropriate use of avermectin/milbemycin or macrocyclic lactone (ML) anthelmintics in sheep, to ensure effective worm control and to minimise selection for ML resistance. Strategy The principles were based on an assessment of the information currently available. The MLs were categorised into three groups (ivermectin [IVM], abamectin [ABA] and moxidectin [MOX]) based on structural differences, persistence and efficacy against ML resistant strains. The reported order of activity or efficacy against ML resistant worm strains was IVM