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Polycystic kidney disease in Bull Terriers: an autosomal dominant inherited disorder
Author(s) -
O'LEARY CA,
MACKAY BM,
MALIK R.,
EDMONDSTON JE,
ROBINSON WF,
HUXTABLE CR
Publication year - 1999
Publication title -
australian veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 59
eISSN - 1751-0813
pISSN - 0005-0423
DOI - 10.1111/j.1751-0813.1999.tb10304.x
Subject(s) - urinalysis , pathology , medicine , polycystic kidney disease , kidney , gross examination , nephron , autosomal dominant polycystic kidney disease , proteinuria , disease , urine
The prevalence, mode of inheritance and urinalysis findings in Bull Terriers with polycystic kidney disease were assessed by screening 150 clinically normal dogs. The disorder was diagnosed in 39 dogs on the basis of renal ultrasound results and family history of the disease. In equivocal cases confirmation required gross and histopathological renal examination. Necropsy was performed on nine affected dogs and the kidneys from another five affected animals were also examined. Renal cysts were usually bilateral, occurred in cortex and medulla and varied from less than 1 mm to over 2.5 cm in diameter. Cysts were lined by epithelial cells of nephron origin. Abnormal urine sediment and proteinuria were common in affected dogs. The disease appears to be inherited in a highly penetrant autosomal dominant manner.