Premium
Plasma cortisol concentrations in normal dogs given hydrocortisone sodium succinate
Author(s) -
CHURCH DB,
LAMB WA,
EMSLIE DR
Publication year - 1999
Publication title -
australian veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 59
eISSN - 1751-0813
pISSN - 0005-0423
DOI - 10.1111/j.1751-0813.1999.tb10271.x
Subject(s) - mineralocorticoid , endocrinology , medicine , glucocorticoid , hydrocortisone , desoxycorticosterone acetate , dexamethasone , sodium , plasma concentration , chemistry , organic chemistry
Objective To evaluate the effects on plasma cortisol concentration of a continuous infusion of a readily available steroid with equipotent glucocorticoid and mineralocorticoid effects. Procedure Plasma cortisol concentrations were measured before and regularly after hydrocortisone sodium succinate was administered as a continuous intravenous infusion over 6 h at 0.32 and 0.65 mg kg ‐1 h ‐1 to 12 healthy dogs weighing 12 to 22 kg. Results The infusion at both dose rates produced significant and stable increases in plasma cortisol concentrations. The plateau concentrations produced by the large and small doeses were respectively above and below plasma cortisol concentrations likely to provide adequate glucocorticoid and mineralocorticoid activity in stressed dogs with significantly decreased adrenal function. Conclusion This paper presents information regarding the changes in plasma cortisol concentrations in 12 normal dogs given an hydrocortisone sodium succinate infusion at two dose rates. The marked and continuous increase in plasma cortisol concentrations suggests a continuous HSS infusion may be a possible alternative to desoxycorticosterone acetate and dexamethasone in the treatment of acute adrenal dysfunction.