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Mitotane (o, DDD) resistance in a dog with pituitary‐dependent hyperadrenocorticism and phaeochromocytoma
Author(s) -
BENNETT PF,
NORMAN EJ
Publication year - 1998
Publication title -
australian veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 59
eISSN - 1751-0813
pISSN - 0005-0423
DOI - 10.1111/j.1751-0813.1998.tb14536.x
Subject(s) - polyuria , mitotane , medicine , polydipsia , endocrinology , chromophobe cell , pars intermedia , dexamethasone , pituitary gland , adenoma , adrenocortical carcinoma , hormone , carcinoma , diabetes mellitus , clear cell
A dog was presented with a 2 year history of polyuria and polydipsia due to pituitary‐dependent hyperadrenocorticism. A low‐dose dexamethasone suppression test and measurement of plasma ACTH concentration confirmed the diagnosis. Treatment was instituted with mitotane at 44 mg/kg/day and then 88 mg/kg/d without complete resolution of signs. The dog collapsed with signs consistent with liver disease and was euthanased. Necropsy revealed a phaeochromocytoma of the left adrenal medulla with extensive metastases to the liver. A chromophobe adenoma of the pars intermedia of the pituitary was found.