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Efficacy of an ivermectin and pyrantel pamoate combination against adult hookworm, Ancylostoma braziliense , in dogs
Author(s) -
SHOOP WL,
MICHAEL BF,
SOLL MD,
CLARK JN
Publication year - 1996
Publication title -
australian veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 59
eISSN - 1751-0813
pISSN - 0005-0423
DOI - 10.1111/j.1751-0813.1996.tb09981.x
Subject(s) - ivermectin , pyrantel , ancylostoma caninum , anthelmintic , veterinary medicine , dirofilaria immitis , biology , medicine , helminths , immunology
SUMMARY A chewable tablet incorporating ivermectin and pyrantel was tested in 12 Beagle dogs for efficacy against the adult hookworm, Ancylostoma braziliense . The dogs were administered infective larvae of A braziliense orally. Twenty‐one days after infection the dogs were weighed and allocated randomly to receive either an oral treatment with ivermectin and pyrantel in a beef‐based chewable tablet or no treatment. The chewable tablet was a commercially available product, which was made to deliver ivermectin at 6 μg/kg and pyrantel at 5.0 mg/kg to each dog. Seven days after treatment the dogs were euthanased, necropsied, and examined for adult hookworms. At necropsy, no adult A braziliense was observed in any of the 6 treated dogs and all 6 dogs that had been left untreated were infected with adult A braziliense (range, 48 to 161). It was concluded that this combination product is 100% efficacious against adult A braziliense .