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Glomerulopathy in dogs with congenital portosystemic shunts
Author(s) -
TISDALL PLC,
ROTHWELL TLW,
HUNT GB,
MALIK R.
Publication year - 1996
Publication title -
australian veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 59
eISSN - 1751-0813
pISSN - 0005-0423
DOI - 10.1111/j.1751-0813.1996.tb09965.x
Subject(s) - glomerulopathy , pathology , medicine , proteinuria , pathological , kidney , portosystemic shunt , immunoperoxidase , urinary system , portal hypertension , cirrhosis , antibody , immunology , monoclonal antibody
SUMMARY Kidney specimens from 12 dogs with congenital portosystemic shunts were examined histologically. Glomerulopathy of variable severity was present in the kidney sections of all 12. Marked irregular thickening of the glomerular capillary wall was the most prominent pathological change, the renal interstitium being largely unaffected. The severity of lesions was not correlated with the age of dogs at the time of necropsy. An immunoperoxidase technique failed to demonstrate significant IgA or IgG deposition in affected glomeruli. Proteinuria was generally mild or absent despite significant glomerular lesions, except in dogs with concurrent urinary tract infection.