Premium
Duration of the persistent activity of moxidectin against Haemonchus contortus in sheep
Author(s) -
ABBOTT KA,
COBB RM,
GLASS M HOLM
Publication year - 1995
Publication title -
australian veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 59
eISSN - 1751-0813
pISSN - 0005-0423
DOI - 10.1111/j.1751-0813.1995.tb06189.x
Subject(s) - moxidectin , haemonchus contortus , ivermectin , domestic sheep reproduction , biology , anthelmintic , veterinary medicine , zoology , persistence (discontinuity) , physiology , helminths , medicine , immunology , geotechnical engineering , engineering
SUMMARY Weaned lambs were infected with Haemonchus contortus 35,28,21,14 and 7 days after treatment with moxidectin at 0.2 mg/kg and 35 and 14 days after treatment with ivermectin at the same dose rate. Worm counts 14 days after infection showed that moxidectin prevented the establishment of over 99% of infective larvae for 28 days and reduced the establishment rate at 35 days by 96%, relative to ivermectin. There was no difference in the protective efficacy of ivermectin at 14 or 35 days. The persistence of moxidectin is likely to provide advantages in nematode control, particularly when used as a strategic early summer treatment or as a pre‐lambing treatment to ewes. Implications of the persistent activity of moxidectin for the development of resistance during the decay phase are discussed.