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The effects of antigenic competition on the efficacy of multivalent footrot vaccines
Author(s) -
SCHWARTZKOFF CL,
EGERTON JR,
STEWART DJ,
LEHRBACH PR,
ELLEMAN TC,
HOYNE PA
Publication year - 1993
Publication title -
australian veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 59
eISSN - 1751-0813
pISSN - 0005-0423
DOI - 10.1111/j.1751-0813.1993.tb06101.x
Subject(s) - antigen , pilus , microbiology and biotechnology , biology , competition (biology) , virology , immunology , virulence , ecology , genetics , gene
SUMMARY A multivalent footrot vaccine has been developed, containing pilus antigens produced in recombinant Pseudomonas aeruginosa and representing all nine serogroups of Dichelobacter (Bacteroides) nodosus commonly recognised in the field. The responses of sheep to the multivalent vaccine have been compared with those to monovalent vaccines representing only a single serogroup. Antigenie competition between serogroups occurred in sheep immunised with the multivalent formulation, but high levels of protection were still achieved. The study showed that in multivalent footrot vaccines, antigenic competition is predominantly due to the presence of a family of immunologically‐related pilus antigens rather than to interference by extraneous proteins.