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Clinical, diagnostic and biochemical features of generalised glycogenosis type II in Brahman cattle
Author(s) -
REICHMANN KG,
TWIST JO,
THISTLETHWAITE EJ
Publication year - 1993
Publication title -
australian veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 59
eISSN - 1751-0813
pISSN - 0005-0423
DOI - 10.1111/j.1751-0813.1993.tb06073.x
Subject(s) - brahman , glycogen , creatine kinase , biology , skeletal muscle , staining , pathology , medicine , endocrinology , physiology , zoology , breed
SUMMARY Clinical, diagnostic and biochemical features of generalised glycogenosis are described In 96 Brahman‐type calves. Typically the calves were presented when about 6 months of age, with III‐thrift and muscular weakness as the most common signs. Acidic α‐glucosidase activity was reduced in peripheral blood lymphocytes and skeletal muscle. Muscle glycogen concentration was consistently higher in affected animals than In clinically normal cattle. Other observations in affected calves Included elevation of serum aspartate amlnotransferase and creatine kinase activities and excessive amounts of high molecular weight oligosaccharides in urine. Fine cytoplasmic vacuolation of neurones In the brain and spinal cord, skeletal muscle, myocardlum and of Purkinje fibres were consistent histological observations. Periodic acid‐Schlff staining revealed the presence of glycogen‐like material In peripheral blood lymphocytes of all affected calves, Indicating that this is a useful aid for the diagnosis of glycogenosis. While 3 of the 96 calves showed somewhat different clinical signs, the similarity of pathology and the biochemical and clinical evidence in the remainder suggested that, In these animals, the disease was expressed as a single syndrome.