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Kanamycin concentrations in synovial fluid after intramuscular administration in the horse
Author(s) -
FIRTH EC,
WHITTEM T,
NOUWS JFM
Publication year - 1993
Publication title -
australian veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 59
eISSN - 1751-0813
pISSN - 0005-0423
DOI - 10.1111/j.1751-0813.1993.tb00871.x
Subject(s) - horse , synovial fluid , medicine , metatarsophalangeal joints , carpal joint , intramuscular injection , kanamycin , surgery , anatomy , anesthesia , chemistry , antibiotics , biology , osteoarthritis , pathology , wrist , paleontology , biochemistry , alternative medicine
SUMMARY Six adult ponies were injected in the same intramuscular site with kanamycin sulphate (10 mg/kg). Two hours later, arthrocenteses of the right metacarpophalangeal, radio‐carpal, intercarpal, tibio‐tarsal and metatarsophalangeal joints were performed within 3 minutes. Arthrocenteses of the same joints on the left side were conducted 5 hours later. When expressed as a percentage of plasma drug concentration, differences in synovial fluid drug concentration between the joints sampled at 2 and 5 hours after injection were not detected.