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Vascular leakage induced by histamine, bradykinin, serotonin and prostaglandin E 2 in Greyhounds
Author(s) -
MILLS PC,
NG JC,
SEA WRIGHT AA,
AUER DE
Publication year - 1993
Publication title -
australian veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 59
eISSN - 1751-0813
pISSN - 0005-0423
DOI - 10.1111/j.1751-0813.1993.tb00791.x
Subject(s) - bradykinin , histamine , serotonin , pharmacology , prostaglandin , prostaglandin e , medicine , chemistry , endocrinology , anesthesia , receptor
SUMMARY Vascular leakage induced by intradermal injection of histamine, bradykinin and serotonin alone and co‐injected with prostaglandin E 2 was measured in Greyhounds using 125 Iodine‐labelled human serum albumin ( 125 I‐HSA) as a marker in the blood. Histamine and bradykinin produced dose‐dependent vascular leakage. At equimolar concentrations, histamine was more than twice as potent as bradykinin. Serotonin did not induce vascular leakage and was irritant. Prostaglandin E 2 did not induce significant vascular leakage (maximum 5μL) when injected alone, but when co‐injected with histamine and bradykinin, the vascular leakage of both histamine and bradykinin was increased. This effect was more pronounced if lower concentrations of histamine and bradykinin were injected. The induced vascular leakage was greatest during the first five minutes of lesion development for histamine, during the second five minutes of lesion development for bradykinin, and the synergistic effect of prostaglandin E 2 was maximal during the third five minute period of lesion development.