Premium
A lupinosis‐associated myopathy in sheep and the effectiveness of treatments to prevent it
Author(s) -
ALLEN JG,
STEELE P.,
MASTERS HG,
LAMBE WJ
Publication year - 1992
Publication title -
australian veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 59
eISSN - 1751-0813
pISSN - 0005-0423
DOI - 10.1111/j.1751-0813.1992.tb15554.x
Subject(s) - myopathy , selenium , tocopherol , creatine kinase , congenital myopathy , creatine , medicine , pathogenesis , endocrinology , chemistry , biochemistry , vitamin e , antioxidant , biopsy , organic chemistry , muscle biopsy
SUMMARY: A lupinosis‐associated myopathy occurred in 26 of 48 sheep given a crude toxic extract of Phomopsis leptostromiformis, and in 18 of 34 sheep that grazed a toxic lupin stubble. Treatment with selenlum or α‐tocopherol alone neither prevented nor cured the myopathy, but selenium and α‐tocopherol together may have been partially effective. Among the group of 48 intoxicated sheep, those with myopathy had a significantly lower mean terminal concentration of α‐tocopherol in their livers than those with no myopathy. There was no relationship between the severity of liver injury and the occurrence of the myopathy. It was considered that this lupinosis‐associated myopathy may have a similar pathogenesis to nutritional myopathy. Data on plasma creatine phosphokinase and erythrocyte glutathione peroxidase activities, plasma α‐tocopherol concentrations and terminal tissue concentrations of selenium and α‐tocopherol are presented.