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Clinical features of ceroid lipofuscinosis in border collie dogs
Author(s) -
STUDDERT VP,
MITTEN RW
Publication year - 1991
Publication title -
australian veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 59
eISSN - 1751-0813
pISSN - 0005-0423
DOI - 10.1111/j.1751-0813.1991.tb03156.x
Subject(s) - neuronal ceroid lipofuscinosis , blindness , medicine , autosomal recessive inheritance , physiology , pediatrics , pathology , biology , genetics , disease , gene , optometry
SUMMARY Ceroid lipofuscinosis was diagnosed by hlstopathological and histochemical findings in 17 related border collie dogs and by clinical signs in 6 of their litter mates. Behavioural changes, first hyperactivlty and later aggression, commenced at 16 to 23 (mean 19.5) months of age. Motor abnormalities and blindness were observed at the mean ages of 20.8 and 21.2 months, respectively. All dogs were euthanased 1 to 6 months after the onset of clinical signs, mean age 23.1 months. Pedigree data supported an autosomal recessive mode of inheritance.