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Immunisation against ovine caseous lymphadenitis: comparison of Corynebacterium pseudotuberculosis vaccines with and without bacterial cells
Author(s) -
EGGLETON DG,
MIDDLETON HD,
DOIDGE CV,
MINTY DW
Publication year - 1991
Publication title -
australian veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 59
eISSN - 1751-0813
pISSN - 0005-0423
DOI - 10.1111/j.1751-0813.1991.tb03085.x
Subject(s) - corynebacterium pseudotuberculosis , caseous lymphadenitis , toxoid , potency , microbiology and biotechnology , corynebacterium , biology , immunization , medicine , immunology , immune system , bacteria , in vitro , biochemistry , genetics
SUMMARY Sheep were immunised with Corynebacterium pseudotuberculosis vaccines prepared from cell‐free toxoid or from toxoid with formalin‐killed cells of C pseudotuberculosis added. Resistance of sheep to infection was tested 6 months after immunisation by inoculation with caseous lymphadenitis pus. The outcome was assessed 3 months later by slaughter and inspection of the sheep for lesions of caseous lymphadenitis. Immunised sheep were adequately protected against infection as shown by a significant reduction in the number of sheep exhibiting lesions compared with control sheep, and by fewer abscesses in affected vaccinated sheep than in affected control sheep. The protective potency of the vaccines was not improved by the inclusion of cells of C pseudotuberculosis.