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Experimental evidence that tryptamine alkaloids do not cause Phalaris aquatica sudden death syndrome in sheep
Author(s) -
BOURKE CA,
CARRIGAN MJ,
DIXON RJ
Publication year - 1988
Publication title -
australian veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 59
eISSN - 1751-0813
pISSN - 0005-0423
DOI - 10.1111/j.1751-0813.1988.tb14462.x
Subject(s) - medicine , toxicity , physiology , oral administration , sudden death , tryptamine , pharmacology
SUMMARY: The acute toxicity for sheep of 3 alkaloids that occur in Phalaris acquatica was examined by intravenous and oral administration. The lowest tested dose rates that produced clinically observed signs were, for 5.methoxy dimethyltryptamine, 0.1 mglkg body weight intravenously and 40 mglkg orally; for gramine, 10 mglkg intravenously and 500 mglkg orally; and for hordenine, 20 mglkg intravenously and 800 mglkg orally. All induced the clinical signs observed in the nervous form of phalaris toxicity, but none induced the cardiac, sudden death, syndrome.