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A Clostridium botulinum type B vaccine for prevention of shaker foal syndrome
Author(s) -
THOMAS R J,
ROSENTHAL D V,
ROGERS R J
Publication year - 1988
Publication title -
australian veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 59
eISSN - 1751-0813
pISSN - 0005-0423
DOI - 10.1111/j.1751-0813.1988.tb07364.x
Subject(s) - foal , antitoxin , immunogenicity , medicine , toxoid , subcutaneous injection , clostridium botulinum , toxin , vaccination , immunology , microbiology and biotechnology , antibody , tetanus , biology , genetics
SUMMARY A toxoid was prepared from type 6 toxin of Clostridium botulinum by treatment with 0.6% formalin for 6 weeks. The toxoid was adsorbed to aluminium hydroxide and this vaccine was evaluated for safety in guinea pigs, mice and horses, and for immunogenicity in guinea pigs and horses. Neutralising antitoxin was demonstrated in adult horses receiving two 2 ml subcutaneous doses 6 weeks apart, and in a foal which suckled its vaccinated dam. Another vaccinated mare and the passively immunised foal were protected against subcutaneous injection of 1600 and 2000 mouse lethal doses of toxin per kg respectively.