Premium
Clinical and pathological observations on goats experimentally infected with Pseudomonas pseudomallei
Author(s) -
THOMAS A D,
FORBESFAULKNER J C,
NORTON J H,
TRUEMAN K F
Publication year - 1988
Publication title -
australian veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 59
eISSN - 1751-0813
pISSN - 0005-0423
DOI - 10.1111/j.1751-0813.1988.tb07350.x
Subject(s) - subcutaneous injection , medicine , spleen , anorexia , intramuscular injection , pseudomonas infection , wasting , chloramphenicol , paresis , antibiotics , biology , pathology , microbiology and biotechnology , immunology , surgery , pseudomonas , bacteria , genetics
SUMMARY The effects in goats of the subcutaneous injection of varying doses of Pseudomonas pseudomallei (90 to 500,000 bacilli) suspended in normal saline are described. High doses ( 500 bacilli) caused acute, fatal infections. Lower doses (90 to 225 bacilli) caused acute or chronic disease when infection became established. However, 11 of 18 goats injected with the lower doses of bacilli showed no sign of infection on clinical or bacteriological examination. Response to antibiotic therapy with long acting tetracycline and chloramphenicol was minimal. Goats surviving the initial phase of infection tended to overcome the disease with a corresponding increase in the number of abscesses that were sterile at necropsy. In infected goats, clinical signs included undulating fever, wasting, anorexia, paresis of the hind legs, severe mastitis and abortion. At necropsy, abscesses were found predominantly in the spleen, lungs, subcutaneous injection site and its draining lymph node.