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The nephrotoxicity of Isotropis forrestii in sheep
Author(s) -
COOPER T B,
HUXTABLE C R,
VOGEL P.
Publication year - 1986
Publication title -
australian veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 59
eISSN - 1751-0813
pISSN - 0005-0423
DOI - 10.1111/j.1751-0813.1986.tb02968.x
Subject(s) - azotemia , glycosuria , oliguria , nephrotoxicity , acute tubular necrosis , necrosis , proteinuria , biology , kidney , pathology , urinary system , medicine , anatomy , endocrinology , renal function , diabetes mellitus
SUMMARY Sheep were drenched with a single toxic dose of dried and milled Isotropis forrestii in water. Intoxication resulted in early onset of glycosuria, enzymuria and proteinuria. Terminal gross lesions included pale kidneys and perirenal oedema. Histologically and ultrastructurally the renal lesions were typical of primary nephrotoxicosis, with extensive proximal tubular epithelial necrosis. The tubular damage was sufficient to cause acute primary renal failure, characterised by oliguria, azotemia and failure of urinary concentrating mechanisms.