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Standards for Clostridium chauvoei vaccine—The relationship between the response of guinea pigs and sheep following vaccination and challenge with virulent C. chauvoei
Author(s) -
CRICHTON R.,
HARRIS D A,
McKAY D J
Publication year - 1986
Publication title -
australian veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 59
eISSN - 1751-0813
pISSN - 0005-0423
DOI - 10.1111/j.1751-0813.1986.tb02931.x
Subject(s) - blackleg , potency , vaccination , biology , virulence , guinea pig , microbiology and biotechnology , new guinea , antigen , virology , veterinary medicine , immunology , medicine , in vitro , history , ethnology , biochemistry , gene , agronomy , brassica , endocrinology
SUMMARY Twelve commercial 5‐component clostridial vaccines with known variations in potency of the blackleg (Clostridium chauvoei ) component, were simultaneously tested in sheep and guinea pigs. Controlled challenge experiments provided evidence of a highly significant correlation in the response of the 2 species. The guinea pig laboratory model is considered to be a valid indicator of field performance for vaccines containing blackleg antigen.