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1,25 dihydroxyvitamin D 3 increases plasma magnesium and calcium in sheep fed liquid diets low in calcium and magnesium
Author(s) -
SCHNEIDER K. M.,
PARKINSON G. B.,
HOUSTON J. C.,
LEAVER D. D.
Publication year - 1985
Publication title -
australian veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 59
eISSN - 1751-0813
pISSN - 0005-0423
DOI - 10.1111/j.1751-0813.1985.tb14144.x
Subject(s) - magnesium , calcium , hypocalcaemia , chemistry , urine , abomasum , phosphorus , endocrinology , medicine , biochemistry , biology , rumen , organic chemistry , fermentation
SUMMARY: Sheep given a liquid diet low in calcium and magnesium by infusion directly into the abomasum developed concurrent hypocalcaemia and hypomagnesaemia, with plasma concentrations of calcium and magnesium decreasing to 2.0 and 0.4 mmol/l respectively. Treatment of these hypomagnesaemic sheep with 1,25 dihydroxyvitamin D 3 (1,25(OH) 2 , D 3 ) increased the plasma calcium, magnesium and phosphorus concentrations with plasma calcium increasing to 2.5 mmol/l and plasma magnesium to 0.6 mmol/l. Plasma magnesium increased despite a small but significant increase in the daily excretion of magnesium in the urine, and the amount of magnesium derived from either bone and/or intestine must have been greater than the amount lost in the urine. Since in other experiments we have demonstrated that plasma calcium remains within the normal range when a liquid diet adequate in magnesium but low in calcium is infused, these results imply that either synthesis of and/or end organ response to 1,25(OH 2 ) D 3 is impaired in magnesium deficient sheep.