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Erythrocyte selenium‐75 uptake as a measure of selenium status in weaner sheep, and its relationship to erythrocyte glutathione peroxidase activity
Author(s) -
JELINEK P. D.,
STEELE P.,
MASTERS H. G.,
ALLEN J. G.,
COPLAND M. D.,
PETTERSON D. S.
Publication year - 1985
Publication title -
australian veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 59
eISSN - 1751-0813
pISSN - 0005-0423
DOI - 10.1111/j.1751-0813.1985.tb07651.x
Subject(s) - selenium , glutathione peroxidase , myopathy , peroxidase , zoology , medicine , biology , chemistry , glutathione , endocrinology , biochemistry , enzyme , organic chemistry
SUMMARY The relationship between in vitro erythrocyte 75 Se uptake ( 75 Se uptake) and erythrocyte glutathlone peroxidase (EGSHPx) activity was examined in weaner sheep during periods of selenium depletion and repletion, to determine whether 75Se uptake was better correlated than EGSHPx activity to the development of weaner nutritional myopathy. In the 2 trials conducted, only 3 of 45 Merino wether weaners developed clinical myopathy and histological lesions in skeletal muscles. The 75Se uptake values and EGSHPx activities in these 3 sheep were no different from those in the unaffected sheep. There was a significant negative correlation between 75 Se uptake values and EGSHPx activities over the entire period of the trials. It could not be demonstrated that 75 Se uptake was any better correlated than EGSHPx activity to the development of nutritional myopathy, and it was concluded that EGSHPx activity indicated selenium status better than 75Se uptake in weaner sheep.