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Changes in the synovia after the intra‐articular injection of sodium hyaluronate into normal horse joints and after arthrotomy and experimental cartilage damage
Author(s) -
HILBERT B. J.,
ROWLEY G.,
ANTONASS K. N.,
McGILL C. A.,
REYNOLDSON J. A.,
HAWKINS C. D.
Publication year - 1985
Publication title -
australian veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 59
eISSN - 1751-0813
pISSN - 0005-0423
DOI - 10.1111/j.1751-0813.1985.tb07290.x
Subject(s) - arthrotomy , sodium hyaluronate , hyaluronic acid , synovial fluid , chemistry , cartilage , horse , surgery , anatomy , medicine , osteoarthritis , arthroscopy , chromatography , pathology , biology , paleontology , alternative medicine
SUMMARY Sodium hyaluronate was injected into normal horse joints and joints that had undergone an arthrotomy and experimental cartilage damage. The elimination half‐life for hyaluronic acid in normal joints was found to be approximately 96 h. The injection caused a non‐significant increase (42%) in synovial fluid protein concentration and a fall in the intrinisic viscosity of the fluid. In the arthrotomy group the synovial fluid hyaluronic acid concentration fell after surgery but it was unaffected by the injection of sodium hyaluronate. An initial rise in the intrinsic viscosity of the synovial fluid from the arthrotomy group coincided with an increase in protein concentration. However there was no significant difference between the mean intrinsic viscosity or protein concentration in synovia from the control and treated joints at any time after surgery.