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The protection given by pilus and whole cell vaccines of Bacteroides nodosus strain 198 against ovine foot‐rot induced by strains of different serogroups
Author(s) -
STEWART D. J.,
CLARK B. L.,
PETERSON J. E.,
EMERY D. L.,
SMITH E. F.,
GRIFFITHS D. A.,
O'DONNELL I. J.
Publication year - 1985
Publication title -
australian veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 59
eISSN - 1751-0813
pISSN - 0005-0423
DOI - 10.1111/j.1751-0813.1985.tb07277.x
Subject(s) - heterologous , strain (injury) , pilus , microbiology and biotechnology , biology , bacteroides , immunity , foot rot , homologous chromosome , antigen , virology , immune system , virulence , immunology , bacteria , genetics , gene , botany , anatomy
SUMMARY A highly purified pilus vaccine prepared from cells of Bacteroides nodosus strain 198 provided a high level of protection against homologous challenge and small, not statistically significant, levels of protection against challenge with 4 other strains each from different serogroups. In a second experiment, a partially purified pilus vaccine from strain 198 induced significant immunity to 1 of 4 heterologous strains which were different from those used in the first experiment. In a third experiment a strain 198 whole cell vaccine produced significant immunity against 3 of 6 heterologous strains used in the first 2 experiments. There was no obvious relationship between the colony type, degree of piliation and level of cross‐protection obtained against a particular strain. The results provide further evidence that immunogens associated with, but distinct from, the pilus are involved in cross‐protection and that cross‐protective antigens are common to some, but not all, strains.