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Comparison of immune response stimulated in sheep, rabbits and guinea pigs by the administration of multi‐component clostridial vaccines
Author(s) -
WEBSTER A. C.,
FRANK C. L.
Publication year - 1985
Publication title -
australian veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 59
eISSN - 1751-0813
pISSN - 0005-0423
DOI - 10.1111/j.1751-0813.1985.tb07254.x
Subject(s) - potency , immune system , clostridium septicum , biology , guinea pig , virology , veterinary medicine , microbiology and biotechnology , medicine , immunology , in vitro , biochemistry , endocrinology
Summary Over 3 years, the immunogenic responses of various batches of multi‐component clostridial vaccines in sheep, rabbits and guinea pigs were compared. Fully susceptible healthy sheep were found to be more suitable than rabbits or guineas pigs for testing the potency of multi‐component clostridial vaccines containing Clostridium novyi type 6, C. perfringens type D, C. septicum and C. tetani , and recommendations are made that sheep are the preferred species for testing the potency of clostridial vaccines.