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Comparison of the immunogenicity of Newcastle disease virus strains V4, B1 and La Sota in chickens
Author(s) -
WESTBURY H. A.
Publication year - 1984
Publication title -
australian veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 59
eISSN - 1751-0813
pISSN - 0005-0423
DOI - 10.1111/j.1751-0813.1984.tb07120.x
Subject(s) - newcastle disease , immunogenicity , virology , strain (injury) , virus , biology , immunity , virulence , microbiology and biotechnology , immune system , immunology , biochemistry , anatomy , gene
SUMMARY The immunogenicity of the Australian Newcastle disease virus (NDV) strain V4 was compared with that of the International reference preparation of Hitchner B1 and a commercial La Sota strain. Immunity was assessed serologically using the log mean HI titres 21 days after immunisation, the percentage of birds in each group which developed titres greater than 2 s and their resistance to graded challenge doses of the virulent Herts 33/56 strain of NDV. These tests showed that the V4 strain was significantly less immunogenic (P < 0.01) than the B1 or La Sota strains when administered intraocularly (eye drop) or by aerosol methods. When given in the drinking water V4 induced a better immunity (P < 0.01) than the B1 strain in one of 2 experiments.