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Tick (Ixodes holocydus) paralysis in the dog – induction of immunity by injection of toxin
Author(s) -
WRIGHT I. G.,
STONE B. F.,
NEISH A. L.
Publication year - 1983
Publication title -
australian veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 59
eISSN - 1751-0813
pISSN - 0005-0423
DOI - 10.1111/j.1751-0813.1983.tb05872.x
Subject(s) - beagle , paralysis , tick , biology , toxin , ixodes , immunity , immune system , medicine , immunology , virology , microbiology and biotechnology , surgery , ecology
SUMMARY Three beagle dogs were immunised against the paralysing effects of holocyclotoxin, using toxic extracts derived from salivary glands of the Australian paralysis tick, Ixodes holocydus. Upon subsequent challenge with four ED50, of toxin the animals were completely immune, whereas during the early stages 2 of 3 dogs became paralysed after injection with 0.5 ED50. Three immunised beagles, on which 15 I. holocydus ticks had fed, showed no symptoms but a control beagle became paralysed after 4 I. holocydus females fed on it. Treatment was instituted immediately upon the onset of clinical signs and the dog recovered uneventfully.