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Studies on a vaccine against infectious bursal disease
Author(s) -
REECE R. L.,
GOULD J. A.,
HINDMARSH M.
Publication year - 1982
Publication title -
australian veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 59
eISSN - 1751-0813
pISSN - 0005-0423
DOI - 10.1111/j.1751-0813.1982.tb02708.x
Subject(s) - infectious bursal disease , flock , newcastle disease , offspring , bursa of fabricius , haemagglutination inhibition , biology , virus , virology , vaccination , virulence , veterinary medicine , antibody , medicine , immunology , physiology , serology , pregnancy , biochemistry , genetics , gene
SUMMARY An infectious bursal disease vaccine, registered for use in breeder flocks, was studied for efficacy on the day‐old offspring of vaccinated hens and for virulence in susceptible day‐old and 6‐week‐old chickens. When given to susceptible day‐old chicks and 6‐week‐old cockerels, the vaccine was found to induce atrophy and pathology of the bursa of Fabricius similar to that observed in field infections. Chicks vaccinated at day‐old had markedly lowered titres in the haemagglutination inhibition test to Newcastle disease virus, when this was given 2 weeks later, but the response of the 6‐week‐old cockerel was similar to that of control birds. Maternal antibody induced by the vaccine protected chicks against infection at day‐old.