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EVALUATION OF THE POTENTIAL OF SYSTEMIC SLOW RELEASE CHEMICAL TREATMENTS FOR CONTROL OF THE CATTLE TICK (BOOPHILUS MICROPLUS) USING IVERMECTIN
Author(s) -
Nolan J.,
Schnitzerling H. J.,
Bird P.
Publication year - 1981
Publication title -
australian veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 59
eISSN - 1751-0813
pISSN - 0005-0423
DOI - 10.1111/j.1751-0813.1981.tb05778.x
Subject(s) - ivermectin , acaricide , tick , potency , biology , veterinary medicine , zoology , chemical control , metabolite , medicine , in vitro , toxicology , agronomy , endocrinology , biochemistry
SUMMARY Stall and field trials with cattle infested with various acaricide‐resistant strains of cattle tick, have demonstrated the potential of ivermectin as a systemic tickicide. A dosage of 200 μg/kg, administered subcutaneously to animals naturally infested in the field, gave satisfactory tick control for 21 days, after an initial lag period of 2 days immediately following treatment, during which significant numbers of ticks survived. Daily subcutaneous treatments, administered so as to simulate slow release, indicated that a dosage of 15 μg/skg/day should give complete tick control if the chemical could be released continuously from a subcutaneous implant. The potency of ivermectin, assessed by in vitro tests against engorged adults, suggests that the tickicidal activity could be associated with the parent compound per se rather than a metabolite.