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VACCINATION OF PREGNANT COWS WITH LOW DOSES OF BRUCELLA ABORTUS STRAIN 19 VACCINE
Author(s) -
Alton G. G.,
Corner L. A.,
Plackett P.
Publication year - 1980
Publication title -
australian veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 59
eISSN - 1751-0813
pISSN - 0005-0423
DOI - 10.1111/j.1751-0813.1980.tb09561.x
Subject(s) - vaccination , strain (injury) , serology , pregnancy , brucellosis , virulence , brucella , medicine , immunization , group b , biology , virology , microbiology and biotechnology , immunology , antibody , biochemistry , gene , genetics
Two groups, each of 9 Jersey cows, were vaccinated subcutaneously with reduced doses of Brucella abortus strain 19 vaccine (measured by the number of bacteria in the vaccine dose) early in their second pregnancy. Ten weeks later they were challenged, along with a similar group of non‐vaccinated cows, by conjunctival instillation of a virulent strain of B. abortus biotype 1. Cows in Group 1 received 1/20th and those in Group 2 received 1/400th the recommended dose of strain 19. Marked reduction in the serological response to vaccination was seen only in Group 2. Four cows in Group 1 excreted strain 19 after parturition, one of them aborted and another calved prematurely with heavy infection of the placenta and foetus with strain 19 in both cases. Resistance to challenge was similar in both vaccinated groups, and higher than previously demonstrated after conventional calfhood vaccination with strain 19. It is concluded that pregnant cows can be effectively vaccinated by the subcutaneous administration of a dose of strain 19 vaccine containing approximately 3 times 10 8 organisms without undue interference with subsequent serological tests or inconvenience resulting from persistence of strain 19 infection.