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FAILURE OF A SINGLE DOSE OF BRUCELLA ABORTUS STRAIN 19 VACCINE TO PROTECT CATTLE WHEN GIVEN EARLY IN CALFHOOD
Author(s) -
Plackett P.,
Alton G. G.,
Carter P. D.,
Corner L. A.
Publication year - 1980
Publication title -
australian veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 59
eISSN - 1751-0813
pISSN - 0005-0423
DOI - 10.1111/j.1751-0813.1980.tb02632.x
Subject(s) - vaccination , medicine , serology , strain (injury) , pregnancy , brucella abortus , veterinary medicine , brucellosis , virulence , zoology , biology , virology , immunology , antibody , biochemistry , gene , genetics
SUMMARY Groups of heifer calves were vaccinated subcutaneously with the standard dose of strain 19 at the age of 3 to 5 weeks or 5 months. Twelve months after primary vaccination a group of the younger vaccinates were revaccinated with a small dose of strain 19 via the conjunctival sac. The effectiveness of vaccination was assessed by challenge with virulent B. abortus after 5 to 6 months of pregnancy. Animals vaccinated at 3 to 5 weeks, but given no intraconjunctival boost, were not effectively protected, but the group receiving the boost were at least as resistant as those which received the subcutaneous dose at 5 months. The intraconjunctival boost caused only slight and transient serological responses in a few animals.