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IMMUNOPROPHYLAXIS WITH BCG OF EXPERIMENTAL ECHINOCOCCUS MULTILOCULARIS INFECTIONS
Author(s) -
Reuben J. M.,
Tanner C. E.
Publication year - 1979
Publication title -
australian veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 59
eISSN - 1751-0813
pISSN - 0005-0423
DOI - 10.1111/j.1751-0813.1979.tb15243.x
Subject(s) - echinococcus multilocularis , parasite hosting , biology , immunology , cestoda , echinococcus , host (biology) , echinococcosis , complement (music) , helminths , zoology , ecology , computer science , genetics , complementation , world wide web , gene , phenotype
SUMMARY: Infection by the metacestodes of Echinococcus multilocularis is an example of the biological paradox of a proliferating parasite in an immunologically‐competent host. There is evidence that infection with these organisms is regulated. A study of this regulation has shown that hydatid cysts can be effectively treated with complement and that the cellular defence mechanisms of the host can be non‐specifically activated with BCG; treatment with BCG presents an effective prophylactic measure against infection with E. multilocularis . The mechanisms by which parasite infections are regulated can furnish clues to possible prophylactic and therapeutic strategies.