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THE TOXICITY AND EFFICIENCY OF ARECOLINE HYDROBROMIDE IN THE TASMANIAN HYDATID CONTROL PROGRAM
Author(s) -
Gregory G. G.,
McConnell J. D.
Publication year - 1978
Publication title -
australian veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 59
eISSN - 1751-0813
pISSN - 0005-0423
DOI - 10.1111/j.1751-0813.1978.tb02449.x
Subject(s) - arecoline , toxicity , hydrobromide , medicine , acute toxicity , veterinary medicine , physiology , toxicology , biology , chemistry , receptor , muscarinic acetylcholine receptor
SUMMARY Results on the efficiency and toxicity of arecoline hydrobromide during the first 11 years of the hydatid limitation program in Tasmania are presented. A satisfactory mucous purge was obtained from about 80% of dogs when arecoline was used at 3.25 mg/kg and from about 75% when the dose rate was reduced to 1.62 mg/kg of body weight. Arecoline is considered to have a low efficiency in detecting tapeworm infection in individual dogs, but is valuable as a diagnostic aid in groups of dogs. Toxicity was seen as acute cardiac collapse in about 5 dogs per 1000 dosed. Deaths followed in 1 dog in about 9,500.