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PATHOGENICITY OF MYCOBACTERIUM INTRACELLULARE TO PIGS
Author(s) -
Tammemagi L.,
Simmons G. C.
Publication year - 1971
Publication title -
australian veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.382
H-Index - 59
eISSN - 1751-0813
pISSN - 0005-0423
DOI - 10.1111/j.1751-0813.1971.tb15511.x
Subject(s) - serotype , virulence , strain (injury) , lymph , mesenteric lymph nodes , subculture (biology) , lymph node , veterinary medicine , biology , mycobacterium , body weight , pathology , microbiology and biotechnology , medicine , spleen , tuberculosis , anatomy , immunology , biochemistry , gene
Summary The pathologic response of pigs to a strain of M. intracellulare serotype VI was investigated in three trials. Ten mg wet weight of the second subculture maintained on Löwenstein‐Jensen slopes produced a large number of tubercular nodules in the mesenteric lymph node of one pig infected orally, and similar lesions in the iliac lymph nodes of another pig following injection of the culture into the gluteal muscles. The lesions so produced were comparable with those recorded in the outbreak of tubercular lymphadenitis from which the above strain was isolated. In two other trials, variable doses ranging from 1.3 to 63 mg wet weight Löwenstein‐Jensen, harvested from the fourth and fifths subculture of this strain, were administered to 13 pigs. The number and size of lesions produced were much smaller, and in several instances no gross or microscopic lesions were detected. Further work is being done to investigate the factors resulting in decreased virulence of this strain of M. intracellulare for pigs.