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Safety Evaluation of Excessive Ingestion of Mozuku Fucoidan in Human
Author(s) -
Abe Sunao,
Hiramatsu Kimiko,
Ichikawa Osamu,
Kawamoto Hitoshi,
Kasagi Takeshi,
Miki Yasunari,
Kimura Takayuki,
Ikeda Tadasu
Publication year - 2013
Publication title -
journal of food science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 150
eISSN - 1750-3841
pISSN - 0022-1147
DOI - 10.1111/j.1750-3841.2012.02966.x
Subject(s) - fucoidan , ingestion , urine , cholesterol , medicine , polysaccharide , chemistry , endocrinology , physiology , biochemistry
Fucoidan is a sulfated polysaccharide in the brown sea algae. This study was conducted in 20 subjects taking excessive fucoidan up to 4.05 g daily for 2 wk. They recorded questionnaire sheets about their health. Blood and urine were collected before and after 2 wk of ingestion. We found that no disorder was apparent in the test period. Although total cholesterol ( P value 0.017) and low‐density lipoprotein cholesterol ( P value 0.017) showed statistically significant reduction and Cl ( P value 0.002) showed significant increase, nothing deviated from the range of normal values. In conclusion, this study showed no abnormalities in the abdominal, fecal states, blood and urine at all.