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Formation of β‐Cyclodextrin Inclusion Enhances the Stability and Aqueous Solubility of Natural Borneol
Author(s) -
Su Jianyu,
Chen Jianping,
Li Lin,
Li Bing,
Shi Lei,
Chen Ling,
Xu Zhenbo
Publication year - 2012
Publication title -
journal of food science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 150
eISSN - 1750-3841
pISSN - 0022-1147
DOI - 10.1111/j.1750-3841.2012.02713.x
Subject(s) - solubility , differential scanning calorimetry , aqueous solution , chemistry , sublimation (psychology) , borneol , fourier transform infrared spectroscopy , thermal stability , chemical engineering , cyclodextrin , dissolution , materials science , organic chemistry , thermodynamics , medicine , psychology , physics , alternative medicine , traditional chinese medicine , pathology , engineering , psychotherapist
The aims of this study were to optimize the preparation conditions of natural borneol/β‐cyclodextrin (NB/β‐CD) inclusion complex by ultrasound method, and to investigate its improvement of stability and solubility. The complex was characterized by different various spectroscopic techniques including Fourier transform infrared spectroscopy, X‐ray diffractometry, and differential scanning calorimetry. The results demonstrate that NB could be efficiently loaded into β‐CD to form an inclusion complex by ultrasound method at a molar ratio of 1 : 1 and mass ratio of 1 : 6. The complex exhibited different physicochemical characteristics from that of free NB. Typically, formation of β‐CD inclusion significantly enhanced the stability and aqueous solubility of NB. Practical Application: Natural borneol (NB) has the potential to be widely used in the fields of medical and functional food, due to its specificity. However, the disadvantages of unstability in the preparation and storage process due to its easy sublimation and the low water solubility limit its application. This research provides an effective way to improve the solubility and stability of NB by preparing NB/β‐CD inclusion complex. Furthermore, theoretical basis is also provided for the application development of NB.