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Effects of Raspberry Phytochemical Extract on Cell Proliferation, Apoptosis, and Serum Proteomics in a Rat Model
Author(s) -
Chen HongSheng,
Liu Ming,
Shi LiJun,
Zhao JinLu,
Zhang ChunPeng,
Lin LuoQiang,
Liu Yan,
Zhang ShuJun,
Jin JunChao,
Wang Lei,
Shen BaoZhong,
Liu JiaRen
Publication year - 2011
Publication title -
journal of food science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 150
eISSN - 1750-3841
pISSN - 0022-1147
DOI - 10.1111/j.1750-3841.2011.02373.x
Subject(s) - blowing a raspberry , phytochemical , apoptosis , in vivo , antioxidant , proteomics , cell growth , angiogenesis , biology , pharmacology , cell cycle , chemistry , biochemistry , cancer research , food science , microbiology and biotechnology , gene
The red raspberry extract possesses potent antioxidant capacity and anticancerous activity in vitro and in vivo . The objective of this study was to determine whether red raspberry extract affected the cell cycle, angiogenesis, and apoptosis in hepatic lesion tissues from a rat model induced by diethylnitrosamine (DEN) as well as changes of serum proteomics. Rats were treated with red raspberry extract (0.75, 1.5, or 3.0 g/kg of body weight) by gavage starting 2 h after DEN administration and continued for 20 wk. Red raspberry extract inhibited cell proliferation, vascular endothelial growth factor VEGF expression, and induced apoptosis in the hepatic lesion tissues. In addition, 2 protein peaks (2597.93 and 4513.88 m/z ) were identified to differentially express in the 3.0 g/kg body weight and positive control groups by serum proteomics. These results suggest that a dietary supplement with red raspberry effectively protects against chemically induced hepatic lesions in rats.