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Effect of Diallyl Trisulfide on the Pharmacokinetics of Nifedipine in Rats
Author(s) -
Wang Yue,
Zou MeiJuan,
Zhao Nan,
Ren JunGang,
Zhou Hong,
Cheng Gang
Publication year - 2011
Publication title -
journal of food science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 150
eISSN - 1750-3841
pISSN - 0022-1147
DOI - 10.1111/j.1750-3841.2010.01960.x
Subject(s) - nifedipine , diallyl trisulfide , pharmacokinetics , oral administration , chemistry , pharmacology , medicine , biochemistry , calcium , apoptosis , organic chemistry
This study aimed to evaluate the effect of diallyl trisulfide (DATS), a major component derived from garlic, on the pharmacokinetics of nifedipine. Pharmacokinetic parameters of nifedipine were determined in rats following an oral gavage (3 mg/kg) or intravenous administration (0.75 mg/kg) of nifedipine with co‐administration of DATS (20 mg/kg) and long‐term pretreatment of DATS (20 mg/kg/d for 15 consecutive days). Compared to the control groups, higher C max and AUC 0–24 h were observed for oral gavage of nifedipine after short‐term and long‐term pretreatment of DATS, whereas those for intravenous nifedipine were little changed. The oral bioavailabilities of nifedipine were remarkably enhanced via the concomitant use of DATS. In conclusion, DATS increased the oral exposure of nifedipine in rats likely by the modification of intestinal metabolism of nifedipine, indicating that combined use of DATS or DATS‐containing supplement with nifedipine may require caution because high plasma concentrations may lead to an undesired toxicity of this agent. Practical Application: Patients suffering from cardiovascular disease should take caution in combined use of DATS or DATS‐rich garlic supplement with nifedipine because long‐term treatment of DATS could lead high plasma concentrations of nifedipine.