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Induction of Heme Oxygenase‐1 by Whisky Congeners in Human Endothelial Cells
Author(s) -
Suzuki Keiko,
Nemoto Asuka,
Tanaka Izumi,
Koshimizu Seiichi,
Suwa Yoshihide,
Ishihara Hiroshi
Publication year - 2010
Publication title -
journal of food science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 150
eISSN - 1750-3841
pISSN - 0022-1147
DOI - 10.1111/j.1750-3841.2010.01697.x
Subject(s) - heme oxygenase , umbilical vein , chemistry , heme , biochemistry , oxygenase , enzyme , in vitro
It is expected that the production of the cytoprotective heme oxygenase‐1 (HO‐1) protein in endothelial cells would reduce severity of vascular injuries, while phenolic compounds are known to induce HO‐1 mRNA and protein in various cells. We investigated the activation of HO‐1 by whisky, which contains various phenolic substances. The congeners of whisky stored from 4 to 18 y in oak barrels were shown to induce an increase of HO‐1 protein in human umbilical vein endothelial cells, while those of freshly distilled whisky spirit exhibited no activity. To determine the compounds with potent HO‐1‐inducing activity among the whisky congeners, several chemicals that had been reported to exist in whisky or oak barrels were screened, and coniferyl aldehyde and sinapyl aldehyde showed the activity. Thus, compounds that emerged in whisky during barrel storage induced cytoprotective protein, HO‐1, in human endothelial cells.