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American Ginseng Berry Juice Intake Reduces Blood Glucose and Body Weight in ob / ob Mice
Author(s) -
Xie J.T.,
Wang C.Z.,
Ni M.,
Wu J.A.,
Mehendale S.R.,
Aung H.H.,
Foo A.,
Yuan C.S.
Publication year - 2007
Publication title -
journal of food science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 150
eISSN - 1750-3841
pISSN - 0022-1147
DOI - 10.1111/j.1750-3841.2007.00481.x
Subject(s) - berry , ginseng , medicine , diabetes mellitus , body weight , intraperitoneal injection , oral administration , food intake , fruit juice , glucose tolerance test , food science , traditional medicine , pharmacology , chemistry , endocrinology , biology , insulin resistance , botany , alternative medicine , pathology
Diabetes is a serious chronic metabolic disease and has a significant impact on patients' lives and the health care system. We previously observed that the organic solvent extract of American ginseng berry possessed significant antidiabetic effects in obese diabetic ob / ob mice after intraperitoneal injection. If American ginseng berry is useful as a dietary supplement, simple preparation and oral intake would be a convenient, safe, and practical means for consumers. In this study, the simply prepared berry juice was first analyzed using high‐performance liquid chromatography, and then administered orally in the ob / ob mice. The animals received daily berry juice 0.6 mL/kg or vehicle for 10 consecutive days. The results indicated that oral juice administration significantly lowered fasting blood glucose levels, and this effect continued for at least 10 d after cessation of the treatment. Data from intraperitoneal glucose tolerance test demonstrated that there was a notable improvement in glucose tolerance in the juice treated group. In addition, the berry juice significantly reduced body weight. Our data suggest that ginseng berry juice, as a dietary supplement, may have functional efficacy in consumers with diabetes.