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Protective and Alleviative Effects from 4 Cysteine‐Containing Compounds on Ethanol‐Induced Acute Liver Injury through Suppression of Oxidation and Inflammation
Author(s) -
Yan Shenglei,
Yin Meichin
Publication year - 2007
Publication title -
journal of food science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 150
eISSN - 1750-3841
pISSN - 0022-1147
DOI - 10.1111/j.1750-3841.2007.00449.x
Subject(s) - cyp2e1 , glutathione , chemistry , ethanol , catalase , alcohol , pharmacology , oxidative stress , tumor necrosis factor alpha , cysteine , acetylcysteine , inflammation , biochemistry , medicine , antioxidant , metabolism , enzyme , cytochrome p450
In vivo protective and alleviative effects of s‐allyl cysteine (SAC), s‐ethyl cysteine (SEC), s‐methyl cysteine (SMC), and s‐propyl cysteine (SPC) against alcohol‐induced hepatotoxicity in Balb/cA mice were studied. In the preventive study, SAC, SEC, SMC, or SPC, each agent at 1 g/L, was added into the drinking water for 3 wk, and the mice were then treated with ethanol to induce acute liver injury. In the alleviative study, mice were first treated by ethanol followed by the 4 agent treatments for 3 wk. The preintake of these agents significantly attenuated subsequent alcohol‐induced lipid oxidation, glutathione (GSH) depletion, and activity reduction of catalase and glutathione peroxidase ( P < 0.05); also attenuated were the alcohol‐induced elevation of c‐reactive protein (CRP), interleukin‐6 (IL‐6), IL‐10 and tumor necrosis factor (TNF)‐alpha ( P < 0.05). The preintake of these agents also significantly retarded alcohol‐induced cytochrome P450 2E1 (CYP2E1) activity increase ( P < 0.05). In the alleviative study, posttreatments from the 4 agents restored liver GSH content ( P < 0.05); however, only SEC and SPC posttreatments significantly reduced lipid oxidation and alleviated the alcohol‐induced elevation of CRP, IL‐6, IL‐10, and TNF‐alpha ( P < 0.05). SEC and SPC posttreatments also significantly diminished alcohol induced CYP2E1 activity ( P < 0.05). These results support that SEC and SPC could provide both preventive and alleviative effects against alcohol‐induced hepatotoxicity through suppression of oxidation and inflammation.