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Identification of C ‐glycoside Flavonoids as Potential Mutagenic Compounds in Kava
Author(s) -
Jhoo J.W.,
Ang C. Y. W.,
Heinze T. M.,
Deck J.,
Schnackenberg L. K.,
Beger R. D.,
Dragull K.,
Tang C.S.
Publication year - 2007
Publication title -
journal of food science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 150
eISSN - 1750-3841
pISSN - 0022-1147
DOI - 10.1111/j.1750-3841.2007.00278.x
Subject(s) - kava , chemistry , glycoside , flavonoid , traditional medicine , chromatography , stereochemistry , biochemistry , medicine , antioxidant
Kava ( Piper methysticum ) extract products have been implicated in a number of severe hepatotoxicity cases. However, systematic toxicological studies regarding kava consumption have not been reported. In this study, 6 major kavalactones and different solvent fractions of kava roots, leaves, and stem peelings were evaluated for their mutagenic potential. None of the kavalactones was found to be positive in the experimental concentration ranges tested by the umu test (a sensitive test for point mutations). However, among the different solvent fractions, the n ‐butanol fraction of kava leaves was positive. Further investigations using bioassay‐directed isolation and analysis indicated that 2 C ‐glycoside flavonoid compounds accounted for the positive mutagenic results. Two isolated compounds were identified as 2″‐ O ‐rhamnosylvitexin and schaftoside by NMR and MS techniques.