Open AccessPathology of Lacunar Ischemic Stroke in Humans—A Systematic Review
Author(s) -
Bailey Emma L.,
Smith Colin,
Sudlow Cathie L. M.,
Wardlaw Joanna M.
Publication year - 2012
Publication title -
brain pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.986
H-Index - 132
eISSN - 1750-3639
pISSN - 1015-6305
DOI - 10.1111/j.1750-3639.2012.00575.x
Subject(s) - pathological , medicine , pathology , lacunar stroke , asymptomatic , stroke (engine) , disease , parenchyma , ischemic stroke , radiology , ischemia , cardiology , mechanical engineering , engineering
Twenty‐five percent of ischemic strokes are lacunar in type, but the cause remains unclear. Pathological descriptions of lacunar lesions are available but have not been systematically assessed. We therefore systematically summarized studies describing lacunar lesions by extracting data on the number of patients and lesions, clinical details, pathological methods, brain regions and/or vessels examined, and both parenchymal and vascular findings. Among 39 papers describing >4000 lesions (>50% from one study), 15 papers examined patients with a clinical lacunar syndrome. Terminology varied, many studies only reported macroscopic pathology and many lesions were cavitated (ie, old). Aside from symptomatic lesions occurring more often in the internal capsule or caudate nucleus, we found no other differences between symptomatic and asymptomatic patients. Perivascular edema and thickening, inflammation and disintegration of the arteriolar wall were common, whereas vessel occlusion was rare. The causal mechanisms of lacunar stroke remain poorly defined because of methodological inconsistencies and challenges. Standardised pathological definitions based on well‐characterized post‐mortem derived material supported by detailed clinical and imaging data are needed.