Open AccessCommon Molecular Cytogenetic Pathway in Papillary Tumors of the Pineal Region (PTPR)
Author(s) -
Gutenberg Angelika,
Brandis Almuth,
Hong Bujung,
Gunawan Bastian,
Enders Christina,
Schaefer IngaMarie,
Burger Ralf,
Ostertag Helmut,
Gaab Michael,
Krauss Joachim K.,
Füzesi Laszlo
Publication year - 2011
Publication title -
brain pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.986
H-Index - 132
eISSN - 1750-3639
pISSN - 1015-6305
DOI - 10.1111/j.1750-3639.2011.00493.x
Subject(s) - papillary tumor , immunohistochemistry , pathology , central nervous system , comparative genomic hybridization , biology , medicine , neuroscience , genome , gene , genetics
Primary papillary tumors of the central nervous system and particularly the pineal region are rare. Papillary tumor of the pineal region (PTPR) is a recently described neoplasm that has been formally recognized in the 2007 World Health Organization Classification of Tumors of the Nervous System. Because of their rarity, further pheno‐ and genotypical observations as well as therapeutic experience are necessary to differentiate PTPR from other primary or secondary papillary tumors of this region. We herein present three cases of PTPR characterized by local recurrence in two of them. Primary and recurrent tumors were analyzed by immunohistochemistry and comparative genomic hybridization (CGH). From our results clonal chromosomal aberrations can be postulated which seem to be a feasible tool to differentiate PTPRs from other primary or secondary papillary tumors of this region.