Open AccessA 25‐YEAR‐OLD WOMAN WITH A MASS IN THE HIPPOCAMPUS
Author(s) -
Ma Xiaomei,
Ge Junhui,
Wang Liangzhe,
Xia Chunyan,
Liu Huimin,
Li Yuli,
He Jin,
Zhu Weijian
Publication year - 2010
Publication title -
brain pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.986
H-Index - 132
eISSN - 1750-3639
pISSN - 1015-6305
DOI - 10.1111/j.1750-3639.2009.00361.x
Subject(s) - vimentin , immunohistochemistry , pathology , hippocampus , pathological , neurofilament , epilepsy , parenchyma , medicine , biology , anatomy , neuroscience
Angiocentric gliomas (AG) have only recently been described. We encountered a 25-year-old woman with AG who had a history of epilepsy for two years. MRI revealed that there was a solid tumor in the hippocampus. The tumor was totally removed. Histologically, the spindle tumor cells proliferated around small parenchymal vessels with perivascular pseudorosettes. The tumor cells of the hippocampus surface umbilicated forming rosettes. Immunohistochemistry demonstrated positivity for GFAP, Vimentin and S-100, but were negative for neurofilament protein, Syn, CgA and P53. EMA had "dot-like" positive staining. The proliferation index was less than 1%. The location of the tumor and the pathological findings confirm that the diagnose was AG. Epilepsy disappeared after the operation. When fully resected these tumors have a good prognosis.